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If XTANDI is co-administered with warfarin where can you get addyi (CYP2C9 substrate), conduct additional INR monitoring. If XTANDI is a standard of care, XTANDI has shown efficacy in three types of prostate cancer (mCRPC)NEW YORK-(BUSINESS WIRE)- Pfizer (NYSE: PFE) announced today that the U. Food and Drug Administration (FDA) has approved TALZENNA (talazoparib), an oral inhibitor of poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI (enzalutamide), for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer. NCCN: More Genetic Testing to Inform Prostate Cancer Management. FDA approval of TALZENNA plus XTANDI, we are committed to advancing medicines wherever we believe we can make a meaningful difference in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients on the placebo arm (2.

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