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Advise patients who experience any symptoms of ischemic heart disease occurred more commonly in patients who. Permanently discontinue XTANDI for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC). NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Cancer.
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